| Author/systemic treatment type | Number of patients systemic treatment/No systemic treatment | Length of follow up (range) | No. lost to follow up (%) | Overall recurrence/progression in systemic treatment group | Mean time from surgery to recurrence (range) |
| Balke et al. [19] / Bisphosphonates | 25/0 | 27.0 Months (3 - 60) | 0 (0%) | n = 4%, 16.0% | NR |
| Chawla et al. [18] / RANK Ligand Antibody | 281/0 | Overall 10.4 Months (5.3 - 16.7). Cohort 1 (n = 169) - 13.0 months, Cohort 2 (n = 100) - 9.2 months (4.2 - 12.9) | 3 (1.1%) | Cohort 1 n = 6%, 3.5% | Cohort 2 - 723 days |
| Totals | 306/0 | 11.8 months | 1.0% | - | - |